Recent Publications
2024
Savage SA, Bertuch AA.
Different phenotypes with different endings-Telomere biology disorders and cancer predisposition with long telomeres.
Br J Haematol.
2024 Oct 27.
doi: 10.1111/bjh.19851. [Epub ahead of print] Review. PubMed PMID: 39462986.
Ben-Simon Y, Hooper M, Narayan S, Daigle T, Dwivedi D, Way SW, Oster A, Stafford DA, Mich JK, Taormina MJ, Martinez RA, Opitz-Araya X, Roth JR, Allen S, Ayala A, Bakken TE, Barcelli T, Barta S, Bendrick J, Bertagnolli D, Bowlus J, Boyer G, Brouner K, Casian B, Casper T, Chakka AB, Chakrabarty R, Chance RK, Chavan S, Departee M, Donadio N, Dotson N, Egdorf T, Gabitto M, Garcia J, Gary A, Gasperini M, Goldy J, Gore BB, Graybuck L, Greisman N, Haeseleer F, Halterman C, Helback O, Hockemeyer D, Huang C, Huff S, Hunker A, Johansen N, Juneau Z, Kalmbach B, Khem S, Kussick E, Kutsal R, Larsen R, Lee C, Lee AY, Leibly M, Lenz GH, Liang E, Lusk N, Malone J, Mollenkopf T, Morin E, Newman D, Ng L, Ngo K, Omstead V, Oyama A, Pham T, Pom CA, Potekhina L, Ransford S, Rette D, Rimorin C, Rocha D, Ruiz A, Sanchez REA, Sedeno-Cortes A, Sevigny JP, Shapovalova N, Shulga L, Sigler AR, Siverts LA, Somasundaram S, Stewart K, Szelenyi E, Tieu M, Trader C, van Velthoven CTJ, Walker M, Weed N, Wirthlin M, Wood T, Wynalda B, Yao Z, Zhou T, Ariza J, Dee N, Reding M, Ronellenfitch K, Mufti S, Sunkin SM, Smith KA, Esposito L, Waters J, Thyagarajan B, Yao S, Lein ES, Zeng H, Levi BP, Ngai J, Ting J, Tasic B.
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types.
bioRxiv.
2024 Sep 26.
doi: 10.1101/2024.06.10.597244. PubMed PMID: 38915722; PubMed Central PMCID: PMC11195086.
Martin A, Schabort J, Bartke-Croughan R, Tran S, Preetham A, Lu R, Ho R, Gao J, Jenkins S, Boyle J, Ghanim GE, Jagota M, Song YS, Li H, Hockemeyer D.
Dissecting the oncogenic mechanisms of POT1 cancer mutations through deep scanning mutagenesis.
bioRxiv.
2024 Aug 19.
doi: 10.1101/2024.08.19.608636. PubMed PMID: 39229243; PubMed Central PMCID: PMC11370387.
Sanchez SE, Gu Y, Wang Y, Golla A, Martin A, Shomali W, Hockemeyer D, Savage SA, Artandi SE.
Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.
Nat Commun. 2024 Jun 18;15(1):5148.
doi: 10.1038/s41467-024-49007-4. PMID: 38890274; PMCID: PMC11189511.
Busquets O, Li H, Mohieddin Syed K, Jerez PA, Dunnack J, Bu RL, Verma Y, Pangilinan GR, Martin A, Straub J, Du Y, Simon VM, Poser S, Bush Z, Diaz J, Sahagun A, Gao J, Hernandez DG, Levine KS, Booth EO, Bateup HS, Rio DC, Hockemeyer D, Blauwendraat C, Soldner F.
iSCORE-PD: an isogenic stem cell collection to research Parkinson's Disease.
bioRxiv [Preprint]. 2024 Feb 13:2024.02.12.579917.
doi: 10.1101/2024.02.12.579917. PMID: 38405931; PMCID: PMC10888955.
Lorbeer FK, Rieser G, Goel A, Wang M, Oh A, Yeh I, Bastian BC, Hockemeyer D.
Distinct senescence mechanisms restrain progression of dysplastic nevi.
PNAS Nexus.
2024 Feb 15;3(2):pgae041.
doi: 10.1093/pnasnexus/pgae041. PMID: 38371417; PMCID: PMC10873501.
Bredeson JV, Mudd AB, Medina-Ruiz S, Mitros T, Smith OK, Miller KE, Lyons JB, Batra SS, Park J, Berkoff KC, Plott C, Grimwood J, Schmutz J, Aguirre-Figueroa G, Khokha MK, Lane M, Philipp I, Laslo M, Hanken J, Kerdivel G, Buisine N, Sachs LM, Buchholz DR, Kwon T, Smith-Parker H, Gridi-Papp M, Ryan MJ, Denton RD, Malone JH, Wallingford JB, Straight AF, Heald R, Hockemeyer D, Harland RM, Rokhsar DS.
Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs.
Nat Commun. 2024 Jan 17;15(1):579.
doi: 10.1038/s41467-023-43012-9. PMID: 38233380; PMCID: PMC10794172.
2023
Sanchez SE, Gu J, Golla A, Martin A, Shomali W, Hockemeyer D, Savage SA, Artandi SE.
Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.
bioRxiv [Preprint].
2023 Dec 1:2023.11.29.569263.
doi: 10.1101/2023.11.29.569263. PMID: 38077053; PMCID: PMC10705489.
Erdmann-Pham DD, Batra SS, Turkalo TK, Durbin J, Blanchette M, Yeh I, Shain H, Bastian BC, Song YS, Rokhsar DS, Hockemeyer D.
Tracing cancer evolution and heterogeneity using Hi-C.
Nat Commun. 2023 Nov 6;14(1):7111.
doi: 10.1038/s41467-023-42651-2. PMID: 37932252; PMCID: PMC10628133.
Li H, Bartke R, Zhao L, Verma Y, Horacek A, Rechav Ben-Natan A, Pangilinan GR, Krishnappa N, Nielsen R, Hockemeyer D.
Nat Biomed Eng. 2024 Feb;8(2):165-176.
doi: 10.1038/s41551-023-01065-7. Epub 2023 Jul 24. PMID: 37488236; PMCID: PMC10878975.
Hunter LA, Wyman S, Packel LJ, Facente SN, Li Y, Harte A, Nicolette G; IGI SARS-CoV-2 Testing Consortium; Di Germanio C, Busch MP, Reingold AL, Petersen ML.
BMJ Open.
2023 Apr 6;13(4):e063999.
doi: 10.1136/bmjopen-2022-063999. PMID: 37024253; PMCID: PMC10083519.
Turkalo TK, Maffia A, Schabort JJ, Regalado SG, Bhakta M, Blanchette M, Spierings DCJ, Lansdorp PM,
Nat Commun. 2023 Feb 20;14(1):939.
doi: 10.1038/s41467-023-36294-6. PMID: 36805596; PMCID: PMC9941109.
2022
Li H, Busquets O, Verma Y, Syed KM, Kutnowski N, Pangilinan GR, Gilbert LA, Bateup HS, Rio DC, Hockemeyer D, Soldner F.
Highly efficient generation of isogenic pluripotent stem cell models using prime editing.
Elife. 2022 Sep 7;11:e79208.
doi: 10.7554/eLife.79208. PMID: 36069759; PMCID: PMC9584603.
Choo S, Lorbeer FK, Regalado SG, Short SB, Wu S, Rieser G, Bertuch AA, Hockemeyer D.
Blood.
2022 Aug 11;140(6):608-618.
doi: 10.1182/blood.2021013750. PMID: 35421215; PMCID: PMC9373014.
2021
BRAIN Initiative Cell Census Network (BICCN).
A multimodal cell census and atlas of the mammalian primary motor cortex.
Nature. 2021 Oct;598(7879):86-102.
doi: 10.1038/s41586-021-03950-0. Epub 2021 Oct 6. PMID: 34616075; PMCID: PMC8494634.
Ehrenberg AJ, Moehle EA, Brook CE, Doudna Cate AH, Witkowsky LB, Sachdeva R, Hirsh A, Barry K, Hamilton JR, Lin-Shiao E, McDevitt S, Valentin-Alvarado L, Letourneau KN, Hunter L, Keller A, Pestal K, Frankino PA, Murley A, Nandakumar D, Stahl EC, Tsuchida CA, Gildea HK, Murdock AG, Hochstrasser ML, O'Brien E, Ciling A, Tsitsiklis A, Worden K, Dugast-Darzacq C, Hays SG, Barber CC, McGarrigle R, Lam EK, Ensminger DC, Bardet L, Sherry C, Harte A, Nicolette G, Giannikopoulos P, Hockemeyer D, Petersen M, Urnov FD, Ringeisen BR, Boots M, Doudna JA; IGI SARS-CoV-2 Testing Consortium.
Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus.
PLoS One.
2021 May 26;16(5):e0251296.
doi: 10.1371/journal.pone.0251296. PMID: 34038425; PMCID: PMC8153421.
Kramer DJ, Aisenberg EE, Kosillo P, Friedmann D, Stafford DA, Lee AY, Luo L, Hockemeyer D, Ngai J, Bateup HS.
Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations.
Cell Rep.
2021 May 11;35(6):109123.
doi: 10.1016/j.celrep.2021.109123. PMID: 33979604; PMCID: PMC8240967.
Kim WT, Hennick K, Johnson J, Finnerty B, Choo S, Short SB, Drubin C, Forster R, McMaster ML, Hockemeyer D.
Cancer-associated POT1 mutations lead to telomere elongation without induction of a DNA damage response.
EMBO J.
2021 Jun 15;40(12):e107346.
doi: 10.15252/embj.2020107346. Epub 2021 May 2. PMID: 33934394; PMCID: PMC8204863.
2020
Schmutz I, Mensenkamp AR, Takai KK, Haadsma M, Spruijt L, de Voer RM, Choo SS, Lorbeer FK, van Grinsven EJ, Hockemeyer D, Jongmans MC, de Lange T.
TINF2 is a haploinsufficient tumor suppressor that limits telomere length.
Elife.
2020 Dec 1;9:e61235.
doi: 10.7554/eLife.61235. PMID: 33258446; PMCID: PMC7707837.
Boyle JM, Hennick KM, Regalado SG, Vogan JM, Zhang X, Collins K, Hockemeyer D.
Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1.
Mol Biol Cell.
2020 Nov 1;31(23):2583-2596.
doi: 10.1091/mbc.E19-08-0447. Epub 2020 Sep 9. PMID: 32903138; PMCID: PMC7851873.
Shin JJ, Schröder MS, Caiado F, Wyman SK, Bray NL, Bordi M, Dewitt MA, Vu JT, Kim WT, Hockemeyer D, Manz MG, Corn JE.
Controlled Cycling and Quiescence Enables Efficient HDR in Engraftment-Enriched Adult Hematopoietic Stem and Progenitor Cells.
Cell Rep. 2020 Sep 1;32(9):108093.
doi: 10.1016/j.celrep.2020.108093. PMID: 32877675; PMCID: PMC7487781.
Mudd AB, Bredeson JV, Baum R, Hockemeyer D, Rokhsar DS.
Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution.
Commun Biol.
2020 Sep 1;3(1):480.
doi: 10.1038/s42003-020-1096-9. PMID: 32873878; PMCID: PMC7463020.
IGI Testing Consortium. Blueprint for a pop-up SARS-CoV-2 testing lab.
Nat Biotechnol.
2020 Jul;38(7):791-797.
doi: 10.1038/s41587-020-0583-3. PMID: 32555529.
Lorbeer FK, Hockemeyer D.
TERT promoter mutations and telomeres during tumorigenesis.
Curr Opin Genet Dev. 2020 Feb;60:56-62.
doi: 10.1016/j.gde.2020.02.001. Epub 2020 Mar 9. PMID: 32163830.
2019
Simic MS, Moehle EA, Schinzel RT, Lorbeer FK, Halloran JJ, Heydari K, Sanchez M, Jullié D, Hockemeyer D, Dillin A.
Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming.
Sci Adv. 2019 Apr 10;5(4):eaaw0025.
doi: 10.1126/sciadv.aaw0025. PMID: 30989118; PMCID: PMC6457941.
2018
Schöneberg J, Dambournet D, Liu TL, Forster R, Hockemeyer D, Betzig E, Drubin DG.
4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell-derived intestinal organoids.
Mol Biol Cell.
2018 Nov 26;29(24):2959-2968.
doi: 10.1091/mbc.E18-06-0375. Epub 2018 Sep 6. PMID: 30188768; PMCID: PMC6329908.
Blair JD, Hockemeyer D, Bateup HS.
Genetically engineered human cortical spheroid models of tuberous sclerosis.
Nat Med.
2018 Oct;24(10):1568-1578.
doi: 10.1038/s41591-018-0139-y. Epub 2018 Aug 20. PMID: 30127391; PMCID: PMC6261470.
Dambournet D, Sochacki KA, Cheng AT, Akamatsu M, Taraska JW, Hockemeyer D, Drubin DG.
Genome-edited human stem cells expressing fluorescently labeled endocytic markers allow quantitative analysis of clathrin-mediated endocytosis during differentiation.
J Cell Biol.
2018 Sep 3;217(9):3301-3311.
doi: 10.1083/jcb.201710084. Epub 2018 Jul 6. PMID: 29980624; PMCID: PMC6123002.
Mir M, Reimer A, Stadler M, Tangara A, Hansen AS, Hockemeyer D, Eisen MB, Garcia H, Darzacq X.
Single Molecule Imaging in Live Embryos Using Lattice Light-Sheet Microscopy.
Methods Mol Biol.
2018;1814:541-559.
doi: 10.1007/978-1-4939-8591-3_32. PMID: 29956254; PMCID: PMC6225527.
Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E.
Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.
Science.
2018 Apr 20;360(6386):eaaq1392.
doi: 10.1126/science.aaq1392. PMID: 29674564; PMCID: PMC6040645.
2017
Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN.
Widespread Translational Remodeling during Human Neuronal Differentiation.
Cell Rep.
2017 Nov 14;21(7):2005-2016.
doi: 10.1016/j.celrep.2017.10.095. PMID: 29141229; PMCID: PMC5759054.
Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D.
Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.
Science.
2017 Sep 29;357(6358):1416-1420.
doi: 10.1126/science.aao0535. Epub 2017 Aug 17. PMID: 28818973; PMCID: PMC5942222.
Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV.
Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.
Stem Cell Reports.
2017 Jun 6;8(6):1770-1783.
doi: 10.1016/j.stemcr.2017.04.027. Epub 2017 May 25. PMID: 28552605; PMCID: PMC5470111.
Chiba K, Vogan JM, Wu RA, Gill MS, Zhang X, Collins K, Hockemeyer D.
Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo.
Mol Cell Biol. 2017 Jan 19;37(3):e00541-16.
doi: 10.1128/MCB.00541-16. PMID: 27872149; PMCID: PMC5247607.
2016
Vogan JM, Zhang X, Youmans DT, Regalado SG, Johnson JZ, Hockemeyer D, Collins K.
Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.
Elife.
2016 Aug 15;5:e18221.
doi: 10.7554/eLife.18221. PMID: 27525486; PMCID: PMC5005035.
Hockemeyer D, Jaenisch R.
Induced Pluripotent Stem Cells Meet Genome Editing.
Cell Stem Cell.
2016 May 5;18(5):573-86.
doi: 10.1016/j.stem.2016.04.013. PMID: 27152442; PMCID: PMC4871596.
Blair JD, Bateup HS, Hockemeyer DF.
Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation.
J Vis Exp.
2016 Feb 2;(108):e53583.
doi: 10.3791/53583. PMID: 26863600; PMCID: PMC4781717.
2015
Hockemeyer D, Collins K.
Control of telomerase action at human telomeres.
Nat Struct Mol Biol.
2015 Nov;22(11):848-52.
doi: 10.1038/nsmb.3083. PMID: 26581518; PMCID: PMC4765361.
Johnson JZ, Hockemeyer D.
Human stem cell-based disease modeling: prospects and challenges.
Curr Opin Cell Biol.
2015 Dec;37:84-90.
doi: 10.1016/j.ceb.2015.10.007. Epub 2015 Nov 11. PMID: 26546888.
Chiba K, Johnson JZ, Vogan JM, Wagner T, Boyle JM, Hockemeyer D.
Cancer-associated TERT promoter mutations abrogate telomerase silencing.
Elife.
2015 Jul 21;4:e07918.
doi: 10.7554/eLife.07918. PMID: 26194807; PMCID: PMC4507476.
2014
Kabir S, Hockemeyer D, de Lange T.
TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation.
Cell Rep.
2014 Nov 20;9(4):1273-80.
doi: 10.1016/j.celrep.2014.10.014. Epub 2014 Nov 6. PMID: 25453752; PMCID: PMC4254571.
Chiba K, Hockemeyer D.
Genome editing in human pluripotent stem cells using site-specific nucleases.
Methods Mol Biol.
2015;1239:267-80.
doi: 10.1007/978-1-4939-1862-1_15. PMID: 25408412.
Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D.
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.
Genes Dev.
2014 Sep 1;28(17):1885-99.
doi: 10.1101/gad.246819.114. Epub 2014 Aug 15. PMID: 25128433; PMCID: PMC4197946.
Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D.
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.
Stem Cell Reports.
2014 Jun 3;2(6):838-52.
doi: 10.1016/j.stemcr.2014.05.001. Erratum in: Stem Cell Reports. 2014 Jul 8;3(1):215. PMID: 24936470; PMCID: PMC4050346.
Forster R, Hockemeyer D.
Genome editing 101: let's go digital.
Nat Methods.
2014 Mar;11(3):248-9.
doi: 10.1038/nmeth.2859. PMID: 24577275.
2013
Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.
Cell Stem Cell.
2013 Oct 3;13(4):446-58.
doi: 10.1016/j.stem.2013.09.001. PMID: 24094325; PMCID: PMC4053296.
2011
Gao Q, Steine EJ, Barrasa MI, Hockemeyer D, Pawlak M, Fu D, Reddy S, Bell GW, Jaenisch R.
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Proc Natl Acad Sci U S A.
2011 Nov 1;108(44):18061-6.
doi: 10.1073/pnas.1114946108. Epub 2011 Oct 19. PMID: 22011581; PMCID: PMC3207684.
Major T, Menon J, Auyeung G, Soldner F, Hockemeyer D, Jaenisch R, Tabar V.
Transgene excision has no impact on in vivo integration of human iPS derived neural precursors.
PLoS One.
2011;6(9):e24687.
doi: 10.1371/journal.pone.0024687. Epub 2011 Sep 22. PMID: 21961042; PMCID: PMC3178523.
Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R.
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.
Cell.
2011 Jul 22;146(2):318-31.
doi: 10.1016/j.cell.2011.06.019. Epub 2011 Jul 14. Erratum in: Cell. 2011 Aug 19;146(4):659. PMID: 21757228; PMCID: PMC3155290.
Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R.
Genetic engineering of human pluripotent cells using TALE nucleases.
Nat Biotechnol.
2011 Jul 7;29(8):731-4.
doi: 10.1038/nbt.1927. PMID: 21738127; PMCID: PMC3152587.
2010
Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O.
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Proc Natl Acad Sci U S A.
2010 Sep 7;107(36):15921-6.
doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23. PMID: 20798034; PMCID: PMC2936617.
Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA.
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells.
Cell Stem Cell.
2010 Aug 6;7(2):249-57.
doi: 10.1016/j.stem.2010.06.015. PMID: 20682450; PMCID: PMC3010384.
DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD.
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.
Genome Res.
2010 Aug;20(8):1133-42.
doi: 10.1101/gr.106773.110. Epub 2010 May 27. PMID: 20508142; PMCID: PMC2909576.
2009
Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R.
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.
Nat Biotechnol.
2009 Sep;27(9):851-7.
doi: 10.1038/nbt.1562. Epub 2009 Aug 13. PMID: 19680244; PMCID: PMC4142824.
Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T.
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Cell.
2009 Jul 10;138(1):90-103.
doi: 10.1016/j.cell.2009.06.021. PMID: 19596237; PMCID: PMC2723738.
Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R.
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.
Cell.
2009 Mar 6;136(5):964-77.
doi: 10.1016/j.cell.2009.02.013. PMID: 19269371; PMCID: PMC2787236.
Palm W, Hockemeyer D, Kibe T, de Lange T.
Functional dissection of human and mouse POT1 proteins.
Mol Cell Biol.
2009 Jan;29(2):471-82.
doi: 10.1128/MCB.01352-08. Epub 2008 Oct 27. PMID: 18955498; PMCID: PMC2612509.
2008
Hockemeyer D, Soldner F, Cook EG, Gao Q, Mitalipova M, Jaenisch R.
A drug-inducible system for direct reprogramming of human somatic cells to pluripotency.
Cell Stem Cell.
2008 Sep 11;3(3):346-353.
doi: 10.1016/j.stem.2008.08.014. PMID: 18786421; PMCID: PMC4097107.
Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T.
Engineered telomere degradation models dyskeratosis congenita.
Genes Dev.
2008 Jul 1;22(13):1773-85.
doi: 10.1101/gad.1679208. Epub 2008 Jun 11. PMID: 18550783; PMCID: PMC2492664.
2007
Hockemeyer D , Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD.
Telomere protection by mammalian Pot1 requires interaction with Tpp1.
Nat Struct Mol Biol.
2007 Aug;14(8):754-61.
doi: 10.1038/nsmb1270. Epub 2007 Jul 15. Erratum in: Nat Struct Mol Biol. 2009 May;16(5):572. PMID: 17632522.
2006
Hockemeyer D, Daniels JP, Takai H, de Lange T.
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Cell.
2006 Jul 14;126(1):63-77.
doi: 10.1016/j.cell.2006.04.044. PMID: 16839877.
2005
Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T.
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end.
EMBO J.
2005 Jul 20;24(14):2667-78.
doi: 10.1038/sj.emboj.7600733. Epub 2005 Jun 23. PMID: 15973431; PMCID: PMC1176460.
2004
Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T.
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
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2004 Jul 15;18(14):1649-54.
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SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development.
EMBO J.
2004 Apr 21;23(8):1834-44.
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Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.
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2002
Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN.
Potentiation of serum response factor activity by a family of myocardin-related transcription factors.
Proc Natl Acad Sci U S A.
2002 Nov 12;99(23):14855-60.
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