The Gong Lab -- Publications

"Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithelium."
^{Xia CH, Lin W, Li R, Xing X, Shang G, Zhang H, Gong X}
"Longitudinal study of microphthalmia in connexin 50 knockout mice using spectral-domain optical coherence tomography."
^{Painter T, Ou C, Gong X, Xia CH}
"Identification and Characterization of Retinitis Pigmentosa in a Novel Mouse Model Caused by PDE6B-T592I."
^{Xia CH, Liu H, Li M, Zhang H, Xing X, Gong X}
"Adaptive Optical Two-Photon Fluorescence Microscopy Probes Cellular Organization of Ocular Lenses In Vivo."
^{Paidi SK, Zhang Q, Yang Y, Xia CH, Ji N, Gong X}
"Retinal microvascular and neuronal pathologies probed in vivo by adaptive optical two-photon fluorescence microscopy."
^{Zhang Q, Yang Y, Cao KJ, Chen W, Paidi S, Xia CH, Kramer RH, Gong X, Ji N}
"Age-related changes of lens stiffness in wild-type and Cx46 knockout mice."
^{Stopka W, Libby T, Lin S, Wang E, Xia CH, Gong X}
"Quantitative X-ray tomographic analysis reveals calcium precipitation in cataractogenesis."
^{Li Y, Parkinson DY, Feng J, Xia CH, Gong X}
"Connexin 50-R205G Mutation Perturbs Lens Epithelial Cell Proliferation and Differentiation."
^{Tjahjono N, Xia CH, Li R, Chu S, Wang J, Gong X}
"CP49 and filensin intermediate filaments are essential for formation of cold cataract."
^{Li Y, Liu X, Xia CH, FitzGerald PG, Li R, Wang J, Gong X}
"Essential function of NHE8 in mouse retina demonstrated by AAV-mediated CRISPR/Cas9 knockdown."
^{Xia CH, Li M, Onishi A, Su B, Ferguson I, Kim A, Li L, Gong X}
"Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro."
^{Wang D, Wang E, Liu K, Xia CH, Li S, Gong X}
"Growth of hollow cell spheroids in microbead templated chambers."
^{Wang E, Wang D, Geng A, Seo R, Gong X}
"EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens."
^{Cheng C, Fowler VM, Gong X}
"Screening, genetics, risk factors, and treatment of neonatal cataracts."
^{Li J, Xia CH, Wang E, Yao K, Gong X}
"Knock-in of Cx46 partially rescues fiber defects in lenses lacking Cx50."
^{Wang E, Geng A, Seo R, Maniar A, Gong X}
"Targeted Exome Sequencing of Congenital Cataracts Related Genes: Broadening the Mutation Spectrum and Genotype-Phenotype Correlations in 27 Chinese Han Families."
^{Zhai Y, Li J, Yu W, Zhu S, Yu Y, Wu M, Sun G, Gong X, Yao K}
"A novel splice site mutation of CRYBA3/A1 gene associated with congenital cataract in a Chinese family."
^{Wu MH, Yu YH, Hao QL, Gong XH, Yao K}
"Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization."
^{Wang D, Wang A, Wu F, Qiu X, Li Y, Chu J, Huang WC, Xu K, Gong X, Li S}
"Connexin 50 Regulates Surface Ball-and-Socket Structures and Fiber Cell Organization."
^{Wang E, Geng A, Maniar AM, Mui BW, Gong X}
"Identification and functional analysis of two novel connexin 50 mutations associated with autosome dominant congenital cataracts."
^{Yu Y, Wu M, Chen X, Zhu Y, Gong X, Yao K}
"Differential connexin function enhances self-renewal in glioblastoma."
^{Hitomi M, Deleyrolle LP, Mulkearns-Hubert EE, Jarrar A, Li M, Sinyuk M, Otvos B, Brunet S, Flavahan WA, Hubert CG, Goan W, Hale JS, Alvarado AG, Zhang A, Rohaus M, Oli M, Vedam-Mai V, Fortin JM, Futch HS, Griffith B, Wu Q, Xia CH, Gong X, Ahluwalia MS, Rich JN, Reynolds BA, Lathia JD}
"NHE8 Is Essential for RPE Cell Polarity and Photoreceptor Survival."
^{Xia CH, Liu H, Cheung D, Tang F, Chang B, Li M, Gong X}
"A Novel GJA8 Mutation (p.V44A) Causing Autosomal Dominant Congenital Cataract."
^{Zhu Y, Yu H, Wang W, Gong X, Yao K}
"Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization."
^{Xia CH, Lu E, Zeng J, Gong X}
"EphA2 and Src regulate equatorial cell morphogenesis during lens development."
^{Cheng C, Ansari MM, Cooper JA, Gong X}
"Cataracts and Microphthalmia Caused by a Gja8 Mutation in Extracellular Loop 2."
^{Xia CH, Chang B, Derosa AM, Cheng C, White TW, Gong X}
"Diverse Roles of Eph/ephrin Signaling in the Mouse Lens."
^{Cheng C, Gong X}
"The role of Vldlr in intraretinal angiogenesis in mice."
^{Xia CH, Lu E, Liu H, Du X, Beutler B, Gong X}
"Lens gap junctions in growth, differentiation, and homeostasis."
^{Mathias RT, White TW, Gong X}
"Severe retinal degeneration caused by a novel rhodopsin mutation."
^{Liu H, Wang M, Xia CH, Du X, Flannery JG, Ridge KD, Beutler B, Gong X}
"Papillorenal Syndrome-Causing Missense Mutations in PAX2/Pax2 Result in Hypomorphic Alleles in Mouse and Human."
^{Alur RP, Vijayasarathy C, Brown JD, Mehtani M, Onojafe IF, Sergeev YV, Boobalan E, Jones M, Tang K, Liu H, Xia CH, Gong X, Brooks BP}
"LRP5 Is Required for Vascular Development in Deeper Layers of the Retina."
^{Xia CH, Yablonka-Reuveni Z, Gong X}
"Connexin Mediated Cataract Prevention in Mice."
^{Li L, Cheng C, Xia CH, White TW, Fletcher DA, Gong X}
"Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis."
^{Cheng C, Xia CH, Huang Q, Ding L, Horwitz J, Gong X}
"Mechanism of cataract formation in alphaA-crystallin Y118D mutation."
^{Huang Q, Ding L, Phan KB, Cheng C, Xia CH, Gong X, Horwitz J}
"Interaction between Connexin50 and Mitogen-activated Protein Kinase Signaling in Lens Homeostasis."
^{Shakespeare TI, Sellitto C, Li L, Rubinos C, Gong X, Srinivas M, White TW}
"The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium."
^{DeRosa AM, Mese G, Li L, Sellitto C, Brink PR, Gong X, White TW}
"EPHA2 is associated with age-related cortical cataract in mice and humans."
^{Jun G, Guo H, Klein BE, Klein R, Wang JJ, Mitchell P, Miao H, Lee KE, Joshi T, Buck M, Chugha P, Bardenstein D, Klein AP, Bailey-Wilson JE, Gong X, Spector TD, Andrew T, Hammond CJ, Elston RC, Iyengar SK, Wang B}
"An identical alphaA-crystallin mutation (R54C) leads to recessive cataracts in humans and mice."
^{Gong X}
"A model for familial exudative vitreoretinopathy caused by LPR5 mutations."
^{Xia CH, Liu H, Cheung D, Wang M, Cheng C, Du X, Chang B, Beutler B, Gong X}
"Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation."
^{Li L, Chang B, Cheng C, Chang D, Hawes NL, Xia CH, Gong X}
"Gap junction communication influences intercellular protein distribution in the lens."
^{Cheng C, Xia CH, Li L, White TW, Niimi J, Gong X}
"GammaD-crystallin associated protein aggregation and lens fiber cell denucleation."
^{Wang K, Cheng C, Li L, Liu H, Huang Q, Xia CH, Yao K, Sun P, Horwitz J, Gong X}
"Connexins in lens development and cataractogenesis."
^{Gong X, Cheng C, Xia CH}
"Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis."
^{Xia CH, Liu H, Cheung D, Cheng C, Wang E, Du X, Chang B, Beutler B, Lo WK, Gong X}
"Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout mice."
^{Dunia I, Cibert C, Gong X, Xia CH, Recouvreur M, Levy E, Kumar N, Bloemendal H, Benedetti EL}
Absence of gap junction channels lead to cataractogenesis by reducing g-crystallin."
^{Xia CH, Cheng C, Cheung D, Huang Q, Dunia I, Benedetti LE, Horwitz J, Gong X}
"Arginine 54 and Tyrosine 118 Residues of αA-Crystallin Are Crucial for Lens Formation and Transparency."
^{Xia CH, Chang B, Cheung D, Liu H, Wang M, Huang Q, Horwitz J, Gong X}
"Knock-in of 3 connexin prevents severe cataracts caused by an 8 point mutation."
^{Xia CH, Cheung D, DeRosa AM, Chang B, Lo WK, White TW, Gong X}
"Crystallin γB-I4F Mutant Protein Binds to α-Crystallin and Affects Lens Transparency."
^{Liu H, Du X, Wang M, Huang Q, Ding L, McDonald HW, Yates, JR, Beutler B, Horwitz J, Gong X}
"Special fasciculiform cataract caused by a mutation in the gammaD-crystallin gene."
^{Shentu X, Yao K, Xu W, Zheng S, Hu S, Gong X}
"Bfsp2 mutation found in mouse 129 strains causes the loss of CP49' and induces vimentin-dependent changes in the lens fibre cell cytoskeleton."
^{Sandilands A, Wang X, Hutcheson AM, James J, Prescott AR, Wegener A, Pekny M, Gong X, Quinlan RA}
"Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice."
^{Du X, Tabeta K, Hoebe K, Liu H, Mann N, Mudd S, Crozat K, Sovath S, Gong X, Beutler B}
"Connections between connexins, calcium, and cataracts in the lens."
^{Gao J, Sun X, Martinez-Wittinghan FJ, Gong X, White TW, Mathias RT}
"Dominant cataracts result from incongruous mixing of wild-type lens connexins."
^{Martinez-Wittinghan F.J., Sellitto C, Li L, Gong X, Brink PR, Mathias RT, White TW}
A loss-of-function of a8 connexin (Cx50) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation."
^{Rong P, Wang X, Niesman I, Wu Y, Levy E, Dunia I, Benedetti LE, Gong X}
"c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes."
^{Petrich BG, Gong X, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang Y}
"A Gja8 (a8 connexin) point mutation causes an alteration of a3 connexin and semi-dominant cataracts in Lop10 mice."
^{Chang B, Wang X, Hawes NL, Davisson MT, Ojakian R, Lo WK, Gong X.}
"Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens."
^{Gong X, Wang X, Han J, Niesman I, Huang Q, Horwitz J}
"Gap junctional coupling in lenses from alpha(8) connexin knockout mice."
^{Baldo GJ, Gong X, Martinez-Wittinghan FJ, Kumar NM, Gilula NB, Mathias RT}
"Signal-transducing function of Na+-K+-ATPase is essential for ouabain's effect on [Ca2+]i in rat cardiac myocytes."
^{Tian J, Gong X, Xie Z}
"Lop12, a Mutation in Mouse Crygd Causing Lens Opacity Similar to Human Coppock Cataract."
^{Smith RS, Hawes NL, Chang B, Roderick TH, Akeson EC, Heckenlively JR, Gong X, Wang X, Davisson MT}
Genetic factors influence cataract formation in a3 connexin knockout mice."
^{Gong X, Agopian K, Kumar NM, Gilula NB}
"Gap junctional coupling in lenses lacking α3 connexin."
^{Gong X, Baldo GJ, Kumar NM, Gilula NB, Mathias RT}
"Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family."
^{Gong X, Kaushal S, Ceccarelli E, Bogdanova N, Neville C, Nguyen T, Clark H, Khatib ZA, Valentine M, Look AT, Rosenthal N}
"Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice."
^{Gong X, Li E, Klier GF, Huang Q, Wu Y, Lei H, Kumar NM, Horwitz J, Gilula NB}