College of Chemistry Course Guide

CHEM 113 - Advanced Mechanistic Organic Chemistry (3 Units)

Course Overview

Summary

Chemistry 113 is a periodically offered course that introduces students to physical organic chemistry.

Prerequisites

CHEM 3A/CHEM 12A and CHEM 3B/CHEM 12B

Additional Notes

Topics Covered

  • Molecular Structure, Molecular Orbital Theory and Thermodynamics
  • Strain and Stability
  • Acid-Base Chemistry
  • Energy Surfaces and Kinetic Analysis
  • Experiments Related to Thermodynamics and Kinetics
  • Organic Reaction Mechanisms (Nucleophilic attack on carbonyls, Enolate chemistry, Aldol reaction)
  • Thermal Pericyclic Reactions (Woodward-Hoffman rules for cycloadditions, electrocylizations and sigmatropic rearrangements)

Workload

Coursework

  • 5 Problem Sets (20%)
  • 1 Midterm (30%)
  • Final Exam (50%)

Time Commitment

3 hours of lecture per week. Problem sets take 1-2 hours.

Choosing the Course

When to take

The class is predominantly juniors and seniors with some sophomores, as this is an upper-division elective course for the chemistry major. This course assumes knowledge of Organic I/II, so it’s a good idea to take this after taking Chem 3A/B or 12A/B. No knowledge of quantum mechanics or statistical mechanics (Chem 120A/B) is required, although the class does touch on Transition State Theory which is usually covered in Chem 120B.

Note that this class is only offered in the fall.

What Next?

Additional Comments and Tips

The recommended textbook for this course is Anslyn & Dougherty’s Modern Physical Organic Chemistry, a standard physical organic chemistry textbook. I found Ian Fleming’s Molecular Orbitals and Organic Chemical Reactions helpful for the thermal pericyclic reactions section of the class (the last few lectures). Lectures often follow Anslyn & Dougherty quite closely, and it may be helpful to follow along with the textbook or a textbook PDF (easily found online).

Overall, this class was very relaxed, due to the short number of lectures (24 total) and the infrequency of graded assignments (7 total assignments / exams total!). Exams were generally straightforward. Feel free to take this class during a harder semester.

This course is an elective that may fulfill part of the Allied Subjects requirement.




Written by: Edward Mu

Last edited: Fall 2018